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Analysis of EEG and CSF 14-3-3 proteins as adis to the diagnosis of Creutzfeldt-Jakob Disease Neurol 55:811-815, Zerr,I. et al, 2000 See this aricle in Pubmed Article Abstract Data on 1,003 patients with suspected CJD were collected using a standard questionnaire. After follow-up was carried out, complete clinical data and neuropathologic diagnoses were available in 805 cases. In these patients, the sensitivity of the detection of periodic sharp wave complexes in the EEG was 66%, with a specificity of 74%. The detection of 14-3-3 proteins in the CSF correlated with the clinical diagnosis in 94% (sensitivity). The specificity (84%) was higher than that of EEG. A combination of both investigations further increased the sensitivity but decreased the specificity. Incorporation of CSF 14-3-3 analysis in the diagnostic criteria for CJD significantly increases the sensitivity of case definition. Amended diagnostic criteria for CJD are proposed.

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(click to filter results - removes previous filter) electroencephalogram electroencephalogram,abnormalities of Jakob-Creutzfeldt disease neurologic disease,diagnoses of protein 14-3-3,cerebrospinal fluid

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